CSEC BIOLOGY · SECTION C · LESSON C4

Sex Determination and Sex-Linked Inheritance

How X and Y chromosomes determine sex, why the chance of a boy is always 50%, and the inheritance of haemophilia and colour blindness.

Continuity and VariationSO C 2.10≈ 25 min🎮 3 games
Before you start

By the end of this lesson you can…

Step 1 · Watch

Explainer video

5 narrated scenes. Press play, listen and read along — the points appear as they are explained. Use ‹ Prev / Next › or the scene bar to jump to any scene.

LESSON C4 · EXPLAINER

Sex Determination and Sex-Linked Inheritance

Why are boys far more likely than girls to be colour-blind?

Narration uses your device’s built-in voice. No sound? Switch to “Captions only” — the captions advance on their own.

Step 2 · Read

Key notes

Copy these into your notebook in your own words — that is how they stick.

Sex chromosomes

Female XX, male XY. Eggs carry X; sperm carry X or Y.

Probability

Each child has a 50% chance of being male or female, every time.

Sex-linked

Gene carried on X chromosome only (no allele on Y).

Why males affected more

Males have one X; a single recessive allele is expressed.

Carrier

Heterozygous female (XᴴXʰ): normal phenotype, can pass allele to children.

Examples

Haemophilia, red-green colour blindness.

Notation

Write alleles as superscripts on X: Xᴴ, Xʰ; Y carries no allele.

EXAM TIPS & COMMON MISTAKES

  • Always attach sex-linked alleles to the X: write XʰY, never hY.
  • A daughter of a haemophiliac father must be at least a carrier (she gets his X).
  • P1: “one example of a sex-linked disease” = colour blindness (not Down syndrome, which is a chromosome number error).
Step 2 · Learn from examples

Worked examples & study resources

The kind of support a teacher gives after the lesson: worked examples to attempt first, a board illustration, key terms, common misconceptions and memory aids.

Worked example 1

Boy or girl?

A couple has three daughters. What is the chance that their fourth child will be a boy? Use a genetic diagram.
father XY × mother XXXYXXXXXYXXXY2 XX : 2 XY50% girls : 50% boys

Try it in your notebook first, then reveal the solution one step at a time.

  1. Mother: XX — all her eggs carry an X.
  2. Father: XY — half his sperm carry X, half carry Y.
  3. Punnett square: XX, XX, XY, XY → 2 girls : 2 boys.
  4. Each pregnancy is a new, independent event — the earlier children do not change the odds.
  5. So the chance of a boy is 1 in 2 (50%).
Answer. 50%. The sex of each child depends on whether an X- or a Y-carrying sperm fertilises the egg, and every pregnancy is independent of the ones before.
Examiner’s tip. The father’s sperm decides the sex of the child, because only he can pass on a Y chromosome.
Worked example 2

A carrier mother and colour blindness

Red-green colour blindness is caused by a recessive allele (b) on the X chromosome. A woman who is a carrier (XᴮXᵇ) has children with a man with normal vision (XᴮY). Predict the children.
mother XᴮXᵇ × father XᴮYXᴮXᵇXᴮYXᴮXᴮXᴮXᵇXᴮYXᵇYdaughters XᴮXᴮ, XᴮXᵇsons XᴮY, XᵇY

Try it in your notebook first, then reveal the solution one step at a time.

  1. Mother’s eggs: Xᴮ or Xᵇ. Father’s sperm: Xᴮ or Y.
  2. Daughters get the father’s Xᴮ, so they are XᴮXᴮ (normal) or XᴮXᵇ (normal vision, carrier). No daughters are colour blind.
  3. Sons get the father’s Y and one of the mother’s X chromosomes: XᴮY (normal) or XᵇY (colour blind).
  4. So each son has a 50% chance of being colour blind; each daughter has a 50% chance of being a carrier.
Answer. Daughters: all normal vision, half are carriers (XᴮXᵇ). Sons: half normal (XᴮY), half colour blind (XᵇY).
Examiner’s tip. Males have only one X, so a single recessive allele is enough to show the condition — there is no second X to mask it. That is why these conditions are more common in males.
On the board · Genotypes for an X-linked condition
GenotypeSexPhenotype
XᴮXᴮFemaleNormal vision
XᴮXᵇFemaleNormal vision — carrier
XᵇXᵇFemaleColour blind (rare)
XᴮYMaleNormal vision
XᵇYMaleColour blind

Females have two X chromosomes and can be carriers; males have one X and cannot be carriers.

Key terms

Sex chromosomes
The X and Y chromosomes that determine sex (XX female, XY male).
Autosomes
All the chromosomes other than the sex chromosomes (22 pairs in humans).
Sex-linked gene
A gene carried on the X chromosome (and not the Y).
Carrier
A heterozygous female who has the recessive allele but does not show the condition.
Haemophilia
A sex-linked condition in which blood does not clot properly.
Colour blindness
A sex-linked inability to distinguish certain colours, usually red and green.

Common misconceptions

  • ✗ The mother decides whether a baby is a boy or a girl.✓ Every egg carries an X. The sperm decides: X sperm → girl, Y sperm → boy.
  • ✗ Only males can have sex-linked conditions.✓ Females can, if they inherit the recessive allele from both parents — but it is much rarer.
  • ✗ Colour-blind boys inherit it from their fathers.✓ A son gets his X from his mother and his Y from his father, so he inherits the allele from his mother.

Memory aid

“Sons get their X from Mum.” So X-linked conditions pass from carrier mothers to sons.

Real-life link

Haemophilia ran through several European royal families in the 1800s and 1900s. Queen Victoria was a carrier, and the allele passed through her daughters to sons in the Spanish, German and Russian royal families.

Try this

Choose an easily seen family trait and draw a family tree of three generations using squares for males and circles for females. Shade those who show the trait.

Play & practise

Games

3 quick games on this lesson. Earn XP and badges as you play — your best score for each game is saved. Games are for practice and do not change your exam readiness.

Step 3 · Practise

Paper 1 practice — multiple choice

8 items modelled on real CSEC Paper 1 questions. Choose one answer for each, then check. Aim for 80% or better.

Adapted from CSEC P1 2022 & 2023, Item 56

1. One example of a sex-linked disease is

Answer: D. Colour blindness is carried on the X chromosome.
EduTech practice item (SO C2.10)

2. The sex of a human baby is determined by

Answer: C. Sperm carry X or Y.
Based on CSEC P2 May/June 2024, Q2(c)

3. A couple already has three sons. The probability their next child is a girl is

Answer: B. Each conception is independent.
EduTech practice item

4. A carrier woman (XᴴXʰ) and a normal man (XᴴY) have a son. The probability he has haemophilia is

Answer: C. Sons receive either Xᴴ or Xʰ from the mother.
EduTech practice item

5. Why is haemophilia more common in males?

Answer: A. No second X to mask the recessive allele.
Based on CSEC P2 May/June 2024, Q2(d)

6. A woman whose father was haemophiliac and whose mother carried the allele could have genotype

Answer: B. She must receive Xʰ from her father.
EduTech practice item

7. Human males have the sex chromosomes

Answer: A. Males are XY.
EduTech practice item

8. A carrier of a sex-linked recessive condition is

Answer: D. She has one normal and one faulty allele.
Step 4 · Apply

Paper 2 practice — structured questions

Write full answers, then reveal the mark scheme and tick the points you earned (15 marks in total). Your answers are saved on this device.

Based on CSEC P2 May/June 2024, Question 2(c)–(d)

Question 1 [8 marks]

“The probability of a child being male or female is the same each time a child is conceived.”

(a) Determine the accuracy of this statement using a complete genetic diagram and conclusion. [6]

MARK SCHEME — (a) (max 6)

(b) List the TWO possible genotypes of a female whose father is a haemophiliac and whose mother carries the allele. [2]

MARK SCHEME — (b) (max 2)

Based on SO C2.10

Question 2 [7 marks]

Red-green colour blindness is a recessive sex-linked condition (allele Xᵇ).

(a) Explain why colour blindness is more common in males than females. [3]

MARK SCHEME — (a) (max 3)

(b) A colour-blind man (XᵇY) and a woman with normal vision who is not a carrier (XᴮXᴮ) have children. Predict the outcome with a genetic diagram. [4]

MARK SCHEME — (b) (max 4)

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Sources

Where this topic appears in CSEC papers

Find these in your own past-paper booklets for extra timed practice. The practice above is adapted from them.